Identification of hepatic NPC1L1 as an NAFLD risk factor evidenced by ezetimibe‐mediated steatosis prevention and recovery
نویسندگان
چکیده
منابع مشابه
Pathogenesis and Prevention of Hepatic Steatosis.
Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged hepatic lipid storage may lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease. Nonalcoholic hepatic steatosis is associated with obesity, type 2 diabetes, and dysl...
متن کاملKnowledge-Based Identification of Soluble Biomarkers: Hepatic Fibrosis in NAFLD as an Example
The discovery of biomarkers is often performed using high-throughput proteomics-based platforms and is limited to the molecules recognized by a given set of purified and validated antigens or antibodies. Knowledge-based, or systems biology, approaches that involve the analysis of integrated data, predominantly molecular pathways and networks may infer quantitative changes in the levels of biomo...
متن کاملSteatosis Grade is the Most Important Risk Factor for Development of Endothelial Dysfunction in NAFLD
It is shown that there are strong associations between nonalcoholic fatty liver disease (NAFLD) and endothelial dysfunction. The aim of our study was to reveal whether steatosis or fibrosis score is more important in the development of endothelial dysfunction in patients with NAFLD in a prospective manner.This cross-sectional study included 266 subjects. These subjects were divided into 2 group...
متن کاملan investigation into translation of cultural concepts by beginner and advance student using think – aloud protocols
this research aims at answering the questions about translation problems and strategies applied by translators when translating cultural concepts. in order to address this issue, qualitative and quantitative study were conducted on two groups of subjects at imam reza international university of mashhad. these two groups were assigned as beginner and advanced translation students (10 students). ...
The Associations of Anthropometric Parameters and Hepatic Steatosis
Introduction: Non-alcoholic fatty liver disease (NAFLD) is an important health problem globally that characterized as a disease spectrum which includes simple steatosis, non-alcoholic steatohepatitis and liver fibrosis and cirrhosis. The prevalence of NAFLD has significantly increased recently. The aim of this study was to investigate the relationship between anthropometric par...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FASEB BioAdvances
سال: 2019
ISSN: 2573-9832,2573-9832
DOI: 10.1096/fba.2018-00044